Virtual colonoscopy with radiolabeled phospholipid ether analogs
US7700075B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 8, 2005 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Jan 17, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B6/037
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides agents and methods for dual modality virtual colonoscopy that gives both anatomical and functional information using hybrid CT/PET scanning. In preferred embodiments, the present invention provides radiolabeled tumor-specific agents and methods for distinguishing benign polyps from malignant tumors. In further embodiments, the present invention provides compositions and methods useful for distinguishing morphological and functional subregions of a selected region of tissue based on relative levels of phospholipid metabolism. Preferred radiolabeled tumor-specific agents are phospholipid ether analogs labeled with a halogen radioisotope. In certain preferred embodiments, the compositions including radiolabeled phospholipid ether analogs have therapeutic actions in addition to functionally identifying malignant tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.