Non-immunostimulatory antibody and compositions containing the same
US7700099B2 · kind B2 · utility
17Cited by
4References
4Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 17, 2006 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Jun 9, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a non-immunostimulatory antibody which lacks antibody-dependent cell-mediated cytotoxicity, Fc gamma receptor binding and complement-mediated cytotoxicity. In some embodiments, the antibody contains a modified immunoglobulin G2 (IgG2) Fc region with at least one substitution in the B/C loop, FcRn binding domain, and the F/G loop. The antibody of the invention is useful in the preparation of therapeutic antibodies and pharmaceutical compositions and kits containing the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.