Tropoelastin-based protoelastin biomaterials
US7700126B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Sep 28, 2007 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Sep 28, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L31/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Biocompatible materials suitable for use in vascular applications have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal, bone, ceramic or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer. The flexibility in engineering and design makes protoelastin biomaterials suited not only to the production of conduits but any number of other vascular applications that require blood contacting surfaces. Tropoelastin and the subsequently engineered biomaterial protoelastin provide the opportunity to satisfy a large unmet need for a biocompatible material adaptable enough to meet a range of diverse vascular uses. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.