Biomimetic prosthetic ligament and production method thereof

US7700147B2 · kind B2 · utility

Assignee

• L.A.R.S.—LABORATOIRE D'APPLICATION ET DE RECHERCHE SCIENTIFIQUE · FR

Inventors

• Bernard Brulez · Langres, FR
• Jacques-Philippe Laboureau · Dijon, FR
• Veronique Migonney · Eaubonne, FR
• Mihaela Ciobanu · Iași, RO
• Graciela Pavon-Djavid · Puteaux, FR
• Alain Siove · Paris, FR

Key dates

• Filing date: Jan 19, 2004
• Grant date: Apr 20, 2010
• Expiry date: May 21, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2/08
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Biomimetic artificial prostheses which are made from polyester, such as polyethylene terephthalate, and a method for the biomimetic functionalization of such prostheses. The method includes a step involving the grafting of biologically-active polymers or copolymers to the polyester surface of the prostheses, the grafting step consisting of the peroxidation of the surface by ozonation followed by a step including the radical polymerization of a solution of at least one monomer. The method also includes an optional step consisting in impregnating the prostheses with type I and/or II collagen and/or fibronectins. The prostheses thus obtained enable a normal and uniform regrowth of the fibroblasts, thereby significantly improving the biological integration of such polyester prostheses.