Assay for bcr/abl gene rearrangement
US7700279B2 · kind B2 · utility
1Cited by
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28Claims
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Key dates
| Filing date | Dec 18, 2003 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Feb 21, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a simple high-throughput assay for detecting bcr/abl translocations. The method includes qualitative PCR methods for identifying the particular amplified translocation (e1a2 or b2a3/b3a2) and real time PCR for quantifying an amount of bcr/abl transcript (e1a2, b2a3 and b3a2). Quantitative measurement of bcr/abl transcript in accordance with the methods of the invention is useful for monitoring response to therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.