Method for producing polyol-IFN-β conjugate
US7700314B2 · kind B2 · utility
2Cited by
10References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 13, 2007 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Apr 8, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.