Patent · US Active

Method for producing an L-tyrosine over-producing bacterial strain

US7700328B2 · kind B2 · utility

1Cited by

3References

9Claims

0Family size

Assignee

E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

Anthony A. Gatenby · Wilmington, US
Ranjan Patnaik · South San Francisco, US
Fateme Sima Sariaslani · Wilmington, US
Wonchul Suh · Hockessin, US
Tina K. Van Dyk · Wilmington, US

Key dates

Filing date	Jun 7, 2006
Grant date	Apr 20, 2010
Priority date	—
Expiry date	May 25, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P13/225
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.