Synthetic heparin-binding factor analogs

US7700563B2 · kind B2 · utility

Assignees

• BioSurface Engineering Technologies, Inc. · US
• Brookhaven Science Associates, LLC · US

Inventors

• Louis A. Pena · Poquott, US
• Paul O. Zamora · Gaithersburg, US
• Xinhua Lin · Plainview, US
• John D. Glass · Shoreham, US

Key dates

• Filing date: Aug 19, 2003
• Grant date: Apr 20, 2010
• Expiry date: Jan 8, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.