Cephalosporin compounds comprising a C3 thio-methyl moiety substituted with N-containing heterocyclic group, and a C7 thiourea acetamido group, their preparations and uses thereof

US7700581B2 · kind B2 · utility

Assignee

• Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. · CN

Inventors

• Mao-Lin Chen · New Taipei, TW
• Shaoxuan Zhu · Longbeilingcun, CN
• Xuebin Liu · Nanhu, CN
• Chun Luo · San Diego, US
• Shuwen Xu · Tangxia, CN
• Lizhen Zheng · Tangxia, CN
• Fang Ye · Nanhu, CN
• Chenglong Yi · Tangxia, CN
• Xiaona Zhang · Tangxia, CN

Key dates

• Filing date: Jan 31, 2007
• Grant date: Apr 20, 2010
• Expiry date: Aug 10, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are a cephalosporin compound of formula I, the preparation and uses thereof. A method of preparing the cephalosporin compound as disclosed herein comprises reacting a starting cephalosporin comprising a C7 amino group and a C3 thio-methyl moiety substituted with an N-containing heterocyclic group with bromoacetyl bromide and then with a N,N′-bissubstituted thiourea. Methods of treating an infectious disease are also disclosed, comprising administering to a patient in need thereof the pharmaceutical composition disclosed herein.