Hydantoin derivatives as metalloproteinase inhibitors

US7700604B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Balint Gabos · Lund, SE
• Michael Lundkvist · Lund, SE
• Magnus Munck Af Rosenschold · Lund, SE
• Igor Shamovsky · Mölndal, SE
• Pavol Zlatoidsky · Mölndal, SE

Key dates

• Filing date: Dec 14, 2005
• Grant date: Apr 20, 2010
• Expiry date: Dec 14, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.