Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors
US7700728B2 · kind B2 · utility
1Cited by
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9Claims
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Key dates
| Filing date | Mar 24, 2006 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Apr 29, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/705
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides novel materials and screening methods for identifying agonists and antagonists of cell receptors. Methods are disclosed for identifying agonists and antagonists using chimeric receptors comprising the extracellular ligand-binding domain of a first receptor fused with the transmembrane and intracellular domains of a second receptor containing an intracellular immunoreceptor tyrosine-based activation motif (ITAM).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.