Prokaryotic collagen-like proteins and uses thereof
US7700731B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 8, 2009 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Jun 8, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/78
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.