High potency recombinant antibodies and method for producing them
US7700735B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 1, 2001 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Aug 10, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/567
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are of either the neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses, as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for producing high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.