Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability
US7704528B2 · kind B2 · utility
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4References
17Claims
0Family size
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Key dates
| Filing date | Aug 15, 2003 |
| Grant date | Apr 27, 2010 |
| Priority date | — |
| Expiry date | Apr 23, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10° C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.