Implantable system for glucose monitoring using fluorescence quenching

US7704704B2 · kind B2 · utility

Assignee

• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• Bennett L. Ibey · San Antonio, US
• Vamsi K. Yadavalli · Richmond, US
• Rebecca M. Rounds · College Station, US
• Hope T. Beier · College Station, US
• Gerard L. Coté · College Station, US
• Michael V. Pishko · Austin, US

Key dates

• Filing date: Sep 28, 2006
• Grant date: Apr 27, 2010
• Expiry date: Mar 19, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/54366
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce an analyte-dependent signal, and (b) detecting the analyte-dependent signal with a detector. A binding protein may reversibly bind an analyte and/or a ligand. A binding protein may have a higher binding affinity for an analyte than for a ligand. A binding protein and a ligand may each include a fluorophore, the absorption and/or emission properties of which may change in an analyte-dependent manner. A binding protein and/or a ligand may be bound to an active or inactive substrate. Some embodiments of systems, devices, and methods may be practiced in vitro, in situ, and/or in vivo. Systems and/or devices of the disclosure may be configured to be wearable.