Patent · US Active

Uracil reductase inactivators

US7704971B2 · kind B2 · utility

0Cited by

15References

13Claims

0Family size

Assignee

SmithKline Beecham Limited · US

Inventors

Thomas Spector · Durham, US
David J. T. Porter · Raleigh, US
Saad G. Rahim · Sydenham, GB

Key dates

Filing date	Sep 1, 2006
Grant date	Apr 27, 2010
Priority date	—
Expiry date	Aug 26, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, ido, cyano, halo-substituted C1-4 alkyl, C2-6 alkenyl, 1-halo-C2-6 alkenyl and halo-substituted C2-6 alkynyl.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.