Gemcitabine derivatives nanoparticles

US7704972B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITÉ PARIS-SUD · DE

Inventors

• Patrick Couvreur · Palaiseau, FR
• Barbara Stella · Torino, IT
• Luigi Cattel · Pecetto, IT
• Flavio Rocco · Nichelino, IT
• Jack-Michel Renoir · L'Haÿ-les-Roses, FR
• Véronique Rosilio · Paris, FR

Key dates

• Filing date: Jun 23, 2005
• Grant date: Apr 27, 2010
• Expiry date: Jan 23, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns a 2′,2′-difluoro-2′-deoxycytidine derivative of general formula (I), wherein: R1, R2 and R3, identical or different, represent independently of one another, a hydrogen atom or an at least C18 hydrocarbon acyl radical and of such conformation that it is capable of providing the compound of general formula (I), a compacted form in a polar solvent medium, at least one of groups R1, R2 and R3 being other than a hydrogen atom.