Thermogelling polymer blends for biomaterial applications
US7708979B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 30, 2004 |
| Grant date | May 4, 2010 |
| Priority date | — |
| Expiry date | Jul 22, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/38
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Thermogelling polymers are described containing poly (n-isopropyl acrylamide). Solutions of this polymer, copolymers or mixtures of the polymer with a second polymer such as poly(ethylene glycol), poly (vinyl pyrrolidone) or poly(vinyl alcohol) are liquids at room temperature and solids at body temperature. Thus, also provided are methods of implanting a hydrogel into a mammal by injecting the solution as a liquid at a temperature below body temperature into a selected site in the mammal at a temperature below body temperature, which then undergoes thermal phase transition to form a solid hydrogel in situ in the body as the implant warms to body temperature. Methods for using these thermal gelling materials in various applications including nucleus pulposus replacement/augmentation, wound care, disk replacement, cartilage replacement, joint replacement, surgical barriers, gastrointestinal devices, cosmetic and reconstructive surgery, and breast enlargement are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.