Patent · US Active

Nucleic acids encoding mutations in sodium channels related to epilepsy

US7709225B2 · kind B2 · utility

3Cited by

2References

12Claims

0Family size

Assignee

Bionomics Limited · AU

Inventors

Robyn Heather Wallace · Brisbane, AU
John Charles Mulley · Adelaide, AU
Samuel Frank Berkovic · Melbourne, AU

Key dates

Filing date	Oct 31, 2005
Grant date	May 4, 2010
Priority date	—
Expiry date	Aug 24, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/705
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

An isolated nucleic acid molecule encoding a mutant alpha subunit of a mammalian voltage-gated sodium channel, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled sodium channel comprising this mutated subunit so as to produce an epilepsy phenotype, with the proviso that the mutation event is not a C2624T transition or a G4943A transition.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.