Fast metabolic imaging of systems with sparse spectra using spiral CSI
US7709266B2 · kind B2 · utility
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Key dates
| Filing date | Sep 1, 2006 |
| Grant date | May 4, 2010 |
| Priority date | — |
| Expiry date | Feb 5, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of 13C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.