Modulation of gene expression by oligomers targeted to chromosomal DNA

US7709456B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• David R. Corey · Dallas, US
• David S. Shames · Dallas, US
• Bethany A. Janowski · Dallas, US
• John Minna · Dallas, US

Key dates

• Filing date: Nov 13, 2006
• Grant date: May 4, 2010
• Expiry date: Oct 3, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.