Pyridazinone derivatives, methods for their production and their use as pharmaceuticals

US7709466B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Swen Hoelder · London, GB
• Karl Schoenafinger · Alzenau, DE
• David William Will · Schwalbach, DE
• Hans Matter · Langenselbold, DE
• Guenter Mueller · Pocking, DE
• Martin Bossart · Frankfurt am Main, DE

Key dates

• Filing date: Oct 24, 2006
• Grant date: May 4, 2010
• Expiry date: Oct 24, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pyridazinone compounds and their derivatives according to the general formula (I), with the substituents X, R1 and R2 defined herein, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals.These compounds are kinase inhibitors, in particular inhibitors of the kinase GSK-3β (glycogen synthase kinase-3β) which are useful in the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovary syndrome and syndrome X or immunodeficiency.