Patent · US Active

Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and methods for their use as pharmaceuticals

US7709481B2 · kind B2 · utility

4Cited by

3References

30Claims

0Family size

Assignee

Sanofi-Aventis · FR

Inventors

Stefanie Keil · Frankfurt am Main, DE
Matthias Urmann · Eschborn, DE
Patrick Bernardelli · Fontenay-aux-Roses, FR
Maike Glien · Frankfurt am Main, DE
Wolfgang Wendler · Bad Camberg, DE
Karen Chandross · Somerville, US
Lan-Ying Lee · Somerville, US

Key dates

Filing date	Mar 26, 2008
Grant date	May 4, 2010
Priority date	—
Expiry date	Mar 26, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The inventive compounds of the present invention are comprised of phenyl and pyridinyl-1,2,4-oxadiazolone derivatives and their physiologically acceptable salts and functional derivatives that are shown to provide peroxisome proliferator activator receptor (PPARdelta) agonist activity. The compounds of the present invention are comprised of the formula:wherein the substituents R1-R5 and R7-R10 are defined herein. The compounds are therapeutically effective in the regulation and modulation of lipid and carbohydrate metabolism in mammals and are thus suitable for the treatment of diseases such as type-2 diabetes, atherosclerosis, cardiovascular disorders and the like.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.