Interaction between the VHL tumor suppressor and hypoxia inducible factor, and assay methods relating thereto
US7709600B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Jul 29, 2004 |
| Grant date | May 4, 2010 |
| Priority date | — |
| Expiry date | Oct 30, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF α subunit sequences which may modulate this interaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.