Interacting polypeptide comprising a heptapeptide pattern and a cellular penetration domain
US7709606B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 30, 2006 |
| Grant date | May 4, 2010 |
| Priority date | — |
| Expiry date | Nov 22, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to an interacting polypeptide consisting of or comprising a heptapeptide pattern of sequence X1X2X3X4X5X6X7 and a transduction domain, characterized in that it is a chimera polypeptide, the amino acid X7 is located between 5 and 35 amino acids of the C-terminal end of said polypeptide, and that the domain (b) is situated in C-terminal relative to pattern (a). The invention also relates to screening methods for identifying interacting polypeptides capable of modifying the phenotype of a cell and to uses of interacting polypeptides as mentioned in phenotypic screens or for therapeutic purposes. Lastly, the invention concerns interacting polypeptides capable of modifying the function of the HIV-1 Rev viral protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.