Patent · US Active

Transgenic mouse expressing arctic mutation E693G

US7709695B1 · kind B1 · utility

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0References

19Claims

0Family size

Assignee

BioArctic Neruoscience AB · SE

Inventors

Lars Nilsson · Uppsala, SE
Lars Lannfelt · Stockholm, SE
Pär Gellerfors · Lidingö, SE

Key dates

Filing date	Mar 17, 2005
Grant date	May 4, 2010
Priority date	—
Expiry date	Aug 13, 2026

Classification

Technology area (CPC A)Human Necessities
CPC primaryA01K2267/0312
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A transgenic non-human animal expressing at least one transgene including a DNA sequence encoding a heterologous Amyloid Precursor Protein (APP) including at least the Arctic mutation (E693G) and a further AD (Alzheimer's disease) pathogenic mutation or a further transgene affecting AD pathogenesis, which results in increased amounts of intracellular soluble A aggregates, including A peptides. The method of producing the transgenic animal, and methods of screening for therapeutic or diagnostic agents useful in treatment or diagnosis of Alzheimer's disease are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.