Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers
US7713949B2 · kind B2 · utility
0Cited by
14References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 10, 2001 |
| Grant date | May 11, 2010 |
| Priority date | — |
| Expiry date | Jul 23, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.