Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US7713979B2 · kind B2 · utility
2Cited by
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7Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 26, 2005 |
| Grant date | May 11, 2010 |
| Priority date | — |
| Expiry date | Dec 17, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.