Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents
US7714146B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Oct 31, 2007 |
| Grant date | May 11, 2010 |
| Priority date | — |
| Expiry date | Oct 31, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is related to novel azulene-oxindole compounds having formula (I) shown below, wherein one of R1, R2 and R3 represents a moiety of formula (II), each of A1 and A2 independently is nitrogen, oxygen or sulfur, each of the others of R1, R2, R3, R1, R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 is as recited in the specification. The novel compound potentially inhibits multiple kinases and thus can be used to treat some disease like cancer or inflammatory.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.