Medical implant materials containing immobilized transglutaminase
US7718168B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 2, 2001 |
| Grant date | May 18, 2010 |
| Priority date | — |
| Expiry date | Feb 13, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/227
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides a medical implant material comprising mammalian transglutaminase and a polymer, wherein the transglutaminase is provided in the absence of free divalent metal ions and wherein the polymer is associated with the transglutaminase binding protein. Preferably, the transglutaminase is a tissue transglutaminase, which is coated on, impregnated into or covalently linked to the polymer. The polymer may be naturally occuring or synthetic, and may be biodegradable or non-biodegradable. The medical implant material may further comprise a reinforcing agent and/or one or more additional polymers. The invention further provides the use of a mammalian transglutaminase in a method for improving the biocompatibility of a medical implant material, the method comprising the steps of (i) providing a medical implant material comprising a polymer associated with a binding protein for binding the transglutaminase, and (ii) treating said material with a mammalian transglutaminase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.