Assays for identifying modulators of rhomboid polypeptides
US7718391B2 · kind B2 · utility
3Cited by
2References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 13, 2002 |
| Grant date | May 18, 2010 |
| Priority date | — |
| Expiry date | Aug 29, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96433
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to proteins of the conserved Rhomboid family, which are involved in various signalling pathways within cells. Rhomboid proteins are found to possess a novel serine protease activity which cleaves within the transmembrane domain of a polypeptide substrate. Methods and uses of this activity are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.