Patent · US Expired

Substrates for TAFI (A)

US7718406B2 · kind B2 · utility

0Cited by

1References

6Claims

0Family size

Assignee

DSM IP ASSETS B.V. · NL

Inventors

Hugo Ziegler · Witterswil, CH
Dagmar Prasa · Erfurt, DE
Jörg Stürzebecher · Erfurt, DE
Peter Wikstroem · Oberwil, CH

Key dates

Filing date	Dec 6, 2002
Grant date	May 18, 2010
Priority date	—
Expiry date	Sep 14, 2025

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/56
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to compounds of general formula (I) and acid addition salts thereof, where the various symbols have the meanings given in the description and claims, the production and use thereof as substrate for the detection of TAFIa, a fibrinolysis inhibiting enzyme. The detection occurs by using the absorption between 400 and 412 nm, arising as a result of the formation of 3-carboxy-4-nitrothiophenol from Ellman's reagent as a function of time.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.