Glycosylation variants of BACE

US7718413B2 · kind B2 · utility

Assignee

• Elan Pharmaceuticals, Inc. · US

Inventors

• John P. Anderson · Langenfeld, DE
• Lisa McConlogue · Burlingame, US
• Guriqbal Basi · Palo Alto, US
• Sukanto Sinha · San Francisco, US

Key dates

• Filing date: Dec 22, 2008
• Grant date: May 18, 2010
• Expiry date: Dec 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/6478
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences, vectors, and host cells for producing the polypeptides. Crystalline protein compositions formed from the purified polypeptides. Methods of screening for compounds that inhibit Aβ using the polypeptides.