Certain indanyl urea modulators of the cardiac sarcomere

US7718657B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Bradley P. Morgan · Moraga, US
• Erica Anne Kraynack · South San Francisco, US
• Pu-Ping Lu · Foster City, US
• Alex Muci · South San Francisco, US
• David J. Morgans, Jr. · Los Altos, US

Key dates

• Filing date: Dec 13, 2006
• Grant date: May 18, 2010
• Expiry date: Sep 23, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.