Patent · US Active

Imidazole variants as modulators of GABA receptor for the treatment of GI disorders

US7718686B2 · kind B2 · utility

0Cited by

6References

26Claims

0Family size

Assignee

ASTRAZENECA AB · SE

Inventors

Udo Bauer · Achern, DE
Wayne Brailsford · Timrå, SE
Vijay Chhajlani · Uppsala, SE
Bryan Egner · Timrå, SE
Ola Fjellstrom · Timrå, SE
Linda Gustafsson · Timrå, SE
Jan Mattsson · Gothenburg, SE
Karolina Nilsson · Gately Drive, SE
Thomas Olsson · Timrå, SE

Key dates

Filing date	Jun 20, 2005
Grant date	May 18, 2010
Priority date	—
Expiry date	Mar 3, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to novel compounds having a positive allosteric GÀBAB receptor (GDR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). A compound of the general formula I.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.