Attenuated Mycobacterium tuberculosis vaccines
US7722861B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Jan 24, 2003 |
| Grant date | May 25, 2010 |
| Priority date | — |
| Expiry date | Dec 3, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Non-naturally occurring mycobacteria in the Mycobacterium tuberculosis complex are provided. These mycobacteria have a deletion of an RD1 region or a region controlling production of a vitamin, and exhibit attenuated virulence in a mammal when compared to the mycobacteria without the deletion. Also provided are non-naturally occurring mycobacteria that have a deletion of a region controlling production of lysine, and mycobacteria comprising two attenuating deletions. Vaccines comprising these mycobacteria are also provided, as are methods of protecting mammals from virulent mycobacteria using the vaccines. Also provided are methods of preparing these vaccines which include the step of deleting an RD1 region or a region controlling production of a vitamin from a mycobacterium in the M. tuberculosis complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.