Patent · US Active

Polypeptide factor from a thermophilic eubacterial species and use thereof in the production of functional, heterologous proteins in an expression host

US7723072B2 · kind B2 · utility

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9Claims

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Assignee

University of Limerick · IE

Inventors

Joseph Tony Pembroke · Limerick, IE
Stefania Spada · Limerick, IE
John Wall · Limerick, IE

Key dates

Filing date	Nov 23, 2007
Grant date	May 25, 2010
Priority date	—
Expiry date	Dec 24, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H21/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A polypeptide factor derived from the thermophilic eubacterial species Thermus thermophilus has universal protein expression-assisting activity. The polypeptide factor has been named the CzrB protein active in full length or truncated form has the potential to act as a universal protein expression-assisting molecule which can increase the yields of all heterologous proteins produced in E. coli by a mechanism that is independent of the protein being expressed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.