Methods and compositions for treating pachyonychia congenita
US7723314B1 · kind B1 · utility
0Cited by
1References
40Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 2006 |
| Grant date | May 25, 2010 |
| Priority date | — |
| Expiry date | Nov 8, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for treating pachyonychia congenita (PC) by identifying a genetic mutation contributing to PC, preparing a siRNA sequence that inhibits expression of the identified mutation, and administering the siRNA to a cell of a subject afflicted with PC. The siRNA treatment can include silencing of both the mutated and associated wildtype genes for a specific keratin. Specific mutations and inhibitory sequences are identified.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.