Patent · US Active

Stabilized alpha helical peptides and uses thereof

US7723469B2 · kind B2 · utility

115Cited by

26References

1Claims

0Family size

Assignee

DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

Loren D. Walensky · Newton, US
Stanley J. Korsmeyer · Chesterfield, US
Gregory L. Verdine · Boston, US

Key dates

Filing date	Nov 5, 2004
Grant date	May 25, 2010
Priority date	—
Expiry date	Mar 2, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.