Process for preparing organic compounds

US7723550B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Peter Herold · Allschwil, CH
• Robert Mah · Muttenz, CH
• Stefan Stutz · Basel, CH
• Aleksandar Stojanovic · Allschwil, CH
• Isabelle Lyothier · Allschwil, CH
• Dirk Behnke · Weil am Rhein, DE

Key dates

• Filing date: Nov 8, 2007
• Grant date: May 25, 2010
• Expiry date: Jan 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for preparing a compound of the formula (I) in which R1 and R2 are each independently H, C1-C8-alkyl, halogen, polyhalo-C1-C8-alkoxy, polyhalo-C1-C8-alkyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl, or C1-C8-alkoxy-C1-C8-alkoxy, where R1 and R2 are not both H, and R3 is C1-C8-alkyl, which is characterized in that a) a compound of the formula (II) in which R1 and R2 are each as defined above and X is Br, I, triflate, toyslate or mesylate is reacted with prop-2-yn-1-ol to give the compound of the formula (III), b) the compound of the formula (III) is reacted with an alkyl-metal compound in which “alkyl” is as defined above for R3 to give a compound of the formula (I).