Potent, selective and non toxic c-kit inhibitors
US7727731B2 · kind B2 · utility
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19References
24Claims
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Key dates
| Filing date | Jun 28, 2002 |
| Grant date | Jun 1, 2010 |
| Priority date | — |
| Expiry date | Jan 16, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a screening method allowing the identification and selection of compounds targeting the transphosphorylase (also called phosphotransferase) domain of c-kit, more particularly compounds selected to be potent inhibitors of constitutively activated c-kit, while being unable to inhibit other activation pathways as for example the pathways leading to death of IL-3 dependent cells cultured in presence of IL-3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.