Method for the preparation of mycophenolate mofetil by enzyme tranesterification
US7727751B2 · kind B2 · utility
4Cited by
0References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 25, 2005 |
| Grant date | Jun 1, 2010 |
| Priority date | — |
| Expiry date | Mar 21, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/162
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of mycophenolate mofetil (MMF) in which an ester of mycophenolic acid (MPA) with a low-molecular-weight aliphatic alcohol is transesterified with N-(2-hydroxyethyl)morpholine in the presence of Candida antarctica lipase, and in which the MPA esterification reaction is carried out in the presence of Candida antarctica lipase using the corresponding alcohol as the solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.