Beta-carbolines useful for treating inflammatory disease
US7727985B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Apr 9, 2004 |
| Grant date | Jun 1, 2010 |
| Priority date | — |
| Expiry date | Dec 23, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides beta-carboline compounds of formula I:wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.