N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives

US7727997B2 · kind B2 · utility

Assignee

• Elan Pharmaceuticals, Inc. · US

Inventors

• Varghese John · San Francisco, US
• Michel Maillard · Redwood Shores, US
• Barbara Jagodzinska · Redwood City, US
• James P. Beck · Zionsville, US
• Andrea Gailunas · San Francisco, US
• John N. Freskos · Clayton, US
• John Mickelson · Mattawan, US
• Lakshman Samala · Plainsboro, US
• Jennifer Sealey · Burlingame, US
• Ruth E. TenBrink · Richland, US
• Larry Fang · Shanghai, CN
• Roy Hom · San Francisco, US

Key dates

• Filing date: Dec 11, 2006
• Grant date: Jun 1, 2010
• Expiry date: Aug 11, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of the formulawherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of disorders such as Alzheimer's Disease.