N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions

US7728008B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Jennifer X. Qiao · Princeton, US
• Tammy C. Wang · Lawrenceville, US
• James Sutton · Princeton Junction, US
• Timur Gungor · Rueil-Malmaison, FR

Key dates

• Filing date: Jun 26, 2006
• Grant date: Jun 1, 2010
• Expiry date: Apr 1, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.