Process for synthesizing compounds useful for treating hepatitis C

US7728027B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Shawn K. Pack · Plainsboro, US
• Peng Geng · Fryeburg, US
• Michael J. Smith · Somerville, US
• Jason Hamm · Clark, US

Key dates

• Filing date: Jul 17, 2008
• Grant date: Jun 1, 2010
• Expiry date: Aug 2, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to intermediates useful in this process.