Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament

US7728134B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Guenter Linz · Mittelbiberach, DE
• Peter Sieger · Mittelbiberach, DE
• Gerd Kraemer · Eberhardzell, DE
• Rolf Herter · Schwabach, DE
• Matthias Hoffmann · Mittelbiberach, DE
• Werner Rall · Mittelbiberach, DE
• Rolf Schmid · Gelterkinden, CH

Key dates

• Filing date: Aug 4, 2005
• Grant date: Jun 1, 2010
• Expiry date: Aug 14, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]Amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide:processes for preparing them and their use as pharmaceutical compositions with antiproliferative activity.