Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
US7728157B2 · kind B2 · utility
1Cited by
27References
1Claims
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Key dates
| Filing date | Mar 21, 2005 |
| Grant date | Jun 1, 2010 |
| Priority date | — |
| Expiry date | May 30, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.