Method for screening an agent that modulates activity of macrophage migration inhibitory factor
US7732146B2 · kind B2 · utility
1Cited by
34References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 15, 2005 |
| Grant date | Jun 8, 2010 |
| Priority date | — |
| Expiry date | Aug 11, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures:including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.