Nucleotide sequences that encode deregulated phosphoglycerate dehydrogenases of coryneform bacteria and method for producing L-serine

US7732176B2 · kind B2 · utility

Assignees

• Forschungszentrum Jülich GmbH · DE
• AMINO CORPORATION · JP

Inventors

• Lothar Eggeling · Jülich, DE
• Petra Peters-Wendisch · Bensberg, DE
• Roman Netzer · Lich, DE
• Hermann Sahm · Jülich, DE
• Robert Faurie · Königslutter am Elm, DE
• Birgit Klassen · Braunschweig, DE

Key dates

• Filing date: Jul 8, 2003
• Grant date: Jun 8, 2010
• Expiry date: Sep 18, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y101/01095
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to nucleotide sequences of coryneform bacteria that encode proteins that are involved in the biosynthesis of L-serine and to a method for producing L-serine. According to the invention, at least 79 amino acids at the C terminus of the wild-type serA sequence are deleted, thereby producing a 3-phosphoglycerate dehydrogenase having a reduced feedback inhibition by L-serine vis-à-vis the wild-type sequence.